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ZytoDot SPEC HER2 Probe

Ref : C-3001-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC HER2 Probe is designed for the detection of HER2 gene amplification, frequently observed in solid malignant neoplasms, in formalin-fixed, paraffin-embedded tissue sections or cell samples. The HER2 gene (a.k.a. ERBB2 and NEU) is located in the chromosomal region 17q12 and encodes the cellular growth factor receptor p185. Amplification of the proto-oncogene HER2, observed in approximately 20% of all breast cancer samples, has been correlated with a poor prognosis of the disease. Similar results have been obtained for a variety of other malignant neoplasms e.g. ovarian cancer, stomach cancer, and carcinomas of the salivary gland.

 

References

Bhargava R, et al. (2005) Am J Clin Pathol 123: 237-43.
Brunello E, et al. (2012) Histopathology 60: 482–8.
Brunner K, et al. (2010) Anal Quant Cytol Histol 32: 78-89.
Coussens L , et al. (1985) Science 230: 1132-9.
Di Palma S, et al. (2008) J Clin Pathol 61: 757-60.
Ettl T, et al. (2012) Hum Pathol 43: 921-31.
Fasching P, et al. (2011) BMC Cancer 11: 486.
Haas M, et al. (2011) Virchows Arch 458: 403-11.
Hauser-Kronberger C & Dandachi N (2004) J Mol Histol 35: 647-53.
Hwang CC, et al. (2011) Histopathology 59: 984–92.
Kounelis S, et al. (2005) Anticancer Res 25: 939-46.
Lehmann-Che L, et al. (2011) Br J Cancer 104: 1739–46.
Moelans CB, et al. (2011) Crit Rev Oncol Hematol 80: 380-92.
Mori N, et al. (2010) Br J Cancer 103: 889-98.
Oliveira-Costa JP, et al. (2011) Diagn Pathol 6: 73.
Shim BY, et al. (2009) Asia Pac J Clin Oncol 5: 232-41.
Tsukamoto T, et al. (1991) Int J Dev Biol 35: 25-32.

 

Probe Description

The ZytoDot ® SPEC HER2 Probe is a Digoxigenin- labeled clone contig specific for the HER2 gene at 17q12, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

 

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the HER2 gene locus or polysomy of chromosome 17 will show multiple dots or large signal clusters.

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