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ZytoDot SPEC ESR1 Probe

Ref : C-3024-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC ESR1 Probe is designed for the detection of ESR1 gene amplification frequently observed in breast cancer. The ESR1 (estrogen receptor 1) gene is located in the chromosomal region 6q25 and encodes estrogen receptor alpha (ER). ER expression is one of the most important known factors in the development of breast cancer, and assessing its status by immunohistochemistry is important for determining the use of anti-estrogen receptor therapies. ESR1 gene amplification has been found frequently in ER-positive breast tumors. Additionally, it has been recently shown for breast cancer patients receiving adjuvant tamoxifen monotherapy that survival is significantly longer in cases of ESR1 gene amplification as determined by FISH compared to immunohistochemically ER-positive cases without gene amplification. Additionally, it has been shown that response to tamoxifen is dependent on the absolute ESR1 copy number. Thus, determination of ESR1 amplification may identify a subgroup of breast cancer patients particularly likely to respond to anti-estrogen therapy.

References

Marchio C, et al. (2008) J Pathol 215: 398-410.
Nembrot M, et al. (1990) Biochem Biophys Res Comm 166: 601-7.
Nessling M, et al. (2005) Cancer Res 65: 439-47.
Holst F, et al. (2007) Nature Genet 39: 655-60.
Lacroix M (2006) Endocr Relat Cancer 13: 1033-67.

 

Probe Description

The ZytoDot ® SPEC ESR1 Probe is a Digoxigenin- labeled clone contig specific for the ESR1 gene region at 6q25, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

 

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the ESR1 gene locus or aneusomy of chromosome 6 will show multiple dots or large signal clusters.

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