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ZytoDot SPEC EGFR Probe

Ref : C-3007-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision


The ZytoDot ® SPEC EGFR Probe is designed for the detection of EGFR gene amplification frequently observed in solid neoplasms including non-small-cell lung cancer (NSCLC) and glioblastoma. The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p12 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. Overexpression of EGFR has been shown in a number of tumor entities and is associated with poor prognosis. EGFR copy number identified by in situ Hybridization is thought to be a molecular predictor in neoplasms.


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Probe Description

The ZytoDot ® SPEC EGFR Probe is a Digoxigenin-labeled clone contig specific for the EGFR gene at 7p12, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.


In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the EGFR gene locus or aneuploidy of chromosome 7 will show multiple dots or large signal clusters.

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