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ZytoDot SPEC EGFR Probe

Ref : C-3007-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC EGFR Probe is designed for the detection of EGFR gene amplification frequently observed in solid neoplasms including non-small-cell lung cancer (NSCLC) and glioblastoma. The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p12 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. Overexpression of EGFR has been shown in a number of tumor entities and is associated with poor prognosis. EGFR copy number identified by in situ Hybridization is thought to be a molecular predictor in neoplasms.

References

Balla P, et al. (2011) Histopathology 59: 376-89.
Brunner K, et al. (2010) 32: 78-89.
Ettl T, et al. (2012) Hum Pathol 43: 921-31.
Isola J & Tanner M (2004) Methods Mol Med 97: 133-44.
Kondo I & Shimizu N (1983) Cytogenet Cell Genet 35: 9-14.
Laurent-Puig P, et al. (2009) J Clin Oncol 27: 5924-30.
Marquez A, et al. (2004) Diagn Mol Pathol 13: 1-8.
Miyazawa H, et al. (2008) Cancer Sci 99: 595-600.
Thomas F, et al. (2007) Clin Cancer Res 13: 7086-92.
Tsukamoto T, et al. (1991) Int J Dev Biol 35: 25-32.
Walker F, et al. (2009) Hum Pathol 40: 1517-27.
Yoo SB, et al. (2010) Lung Cancer 67: 301-5.
Zaczek A, et al. (2005) Histol Histopathol 20: 1005-15.

 

Probe Description

The ZytoDot ® SPEC EGFR Probe is a Digoxigenin-labeled clone contig specific for the EGFR gene at 7p12, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the EGFR gene locus or aneuploidy of chromosome 7 will show multiple dots or large signal clusters.

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