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ZytoDot SPEC CMYC Probe

Ref : C-3013-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision


The ZytoDot ® SPEC CMYC Probe is designed for the detection of CMYC gene amplification frequently observed in malignant tumors e.g. breast and endometrial cancer.
The proto-oncogene CMYC is located in the chromosomal region 8q24 and encodes a nuclear transcription factor displaying high-affinity, site specific DNAbinding capacity when complexed with its cellular partners. Thus, the CMYC protein is involved in proliferation, growth, differentiation, and apoptosis.
Amplification of the chromosomal CMYC gene region has been detected in many types of malignant neoplasms e.g. breast, lung, head, colon, kidney, neck, ovary, bladder, and endometrial cancers. It was shown that CMYC amplification occurs in advanced, widespread tumors or in aggressive, primary tumors. In non-small cell lung cancer (NSCLC) and breast cancer, for example, CMYC amplification
was strongly associated with lymph node status. Accordingly, the CMYC gene can be considered as a powerful prognostic marker.
Additionally, malignant cutaneous angiosarcomas but not benign and atypical vascular lesions occurring after radiotherapy of breast cancer are characterized by amplification of the CMYC gene. The presence of CMYC amplification is thus of considerable diagnostic importance for the distinction of malignant from atypical postradiation vascular neoplasms of the skin.



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Probe Description

The ZytoDot ® SPEC CMYC Probe is a Digoxigenin-labeled clone contig specific for the CMYC gene region at 8q24, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.



In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the CMYC gene locus or polysomy of chromosome 8 will show multiple dots or large signal clusters.

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