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ZytoDot SPEC CCND1 Probe

Ref : C-3034-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC CCND1 Probe is designed for the detection of CCND1 gene amplifications frequently observed in breast cancer and other human tumors.
The cyclin D1 gene (a.k.a. CCND1 or PRAD1) is located in the chromosomal region 11q13 and encodes a regulatory subunit of cyclin-dependent kinases that promote progression through the cell cycle.
The proto-oncogene CCND1 is amplified in a number of solid tumors including approx. 20% of all human breast cancer cases and about 30% of squamous cell carcinomas of the esophagus and the head and neck region. Amplification of chromosomal material from 11q13 harboring the CCND1 gene is discussed as prognostic marker in terms of metastasis, tumor recurrence, and survival for several
tumor entities. In gastrointestinal stromal tumors (GIST), CCND1 amplification was found in 16% of high-risk tumors and was
absent in low- or intermediate-risk tumors indicating the prognostic relevance of this genetic alteration in GIST.

 

References

Al-Kuraya K, et al. (2004) Cancer Res 64: 8534-40.
Courjal F, et al. (1997) Cancer Res 57: 4360-7.
Duprez R, et al. (2012) J Pathol 226: 427-41.
Motokura T, et al. (1991) Nature 350: 512-5.
Ormandy CJ, et al. (2003) Breast Cancer Res Treat 78: 323-35.
Schuuring E (1995) Gene 159: 83-96.
Tornillo L, et al. (2005) Lab Invest 85: 921-31.
Xiong Y, et al. (1991) Cell 65: 691-9.

 

Probe Description

The ZytoDot ® SPEC CCND1 Probe is a Digoxigenin-labeled clone contig specific for the CCND1 gene region at 11q13, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

 

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the CCND1 gene locus or polysomy of chromosome 11 will show multiple dots or large signal clusters.

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