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ZytoDot 2C SPEC SYT Break Apart Probe

Ref : C-3046-100 - Nº Test : 10 - Format : 0,1 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® 2C SPEC SYT Break Apart Probe is designed to detect translocations involving the chromosomal region 18q11 harboring the SYT (synovial sarcoma translocation) gene (a.k.a. SS18).
Translocations involving the region 18q11 are found in over 90% of synovial sarcoma. Among soft tissue sarcomas, synovial sarcoma is one of the most common and classically occurs in the extremities of young adults with greater prevalence in males even though, the occurrence of synovial sarcoma has also been described in a wide variety of anatomical locations and in all ages.
The most frequent translocation involving the SYT gene region is t(X;18) (p11.2;q11.2) juxtaposing the SYT gene in 18q11 either next to the SSX1 (synovial sarcoma, translocated to X chromosome) or the SSX2 gene, or very rarely to the SSX4 locus located in Xp11. Complex translocations involving other chromosomes are observed in less than 10% of synovial sarcomas. In combination with histopathological diagnosis, detection of SYT rearrangements via in situ Hybridization (ISH) analysis is a valuable tool to confirm the diagnosis of synovial sarcoma.

 

References

Amary MF, et al. (2007) Mod Pathol 20: 482-96.
Clark J, et al. (1994) Nat Genet 7: 502-8.
Kawai A, et al. (1998) N Engl J Med 338: 153-60.
Surace C, et al. (2004) Lab Invest 84: 1185-92.
Torres L, et al. (2008) Cancer Genet Cytogenet 187: 45-9.

 

Probe Description

The ZytoDot ® 2C SPEC SYT Break Apart Probe is a mixture of a Digoxigeninlabeled probe and a Dinitrophenyl-labeled probe hybridizing to the 18q11 band.
The DNP-labeled probe hybridizes distal to the SYT gene and the DIG-labeled probe hybridizes proximal to that gene.

 

Results

In an interphase nucleus lacking a translocation involving the 18q11 band, using the ZytoDot ® 2C CISH Implementation Kit two red/green fusion signals are expected representing two normal (non-rearranged) 18q11 loci. A signal pattern consisting of one red/green fusion signal, one red signal, and a separate green signal indicates one normal 18q11 locus and one 18q11 locus affected by an 18q11 translocation.

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