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ZytoDot 2C SPEC MET/CEN 7 Probe

Ref : C-3057-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® 2C SPEC MET/CEN 7 Probe is designed for the detection of MET gene amplifications found in a variety of human tumors.
The MET gene (a. k. a. c-Met) is located in the chromosomal region 7q31.2 and encodes a transmembrane tyrosine kinase receptor for the hepathocyte growth factor (HGF). HGF and MET play an important role in angiogenesis and tumor growth.
Activation or upregulation of MET was found in a number of carcinomas including lung, breast, colorectal, prostate, and gastric carcinomas as well as in gliomas, melanomas and some sarcomas. MET overexpression is known as a negative prognostic indicator in patients with various carcinomas, multiple myeloma, or glioma. Therefore, several inhibitors of the HGF/MET signaling pathway are being studied and developed as potent therapies to inhibit angiogenesis and tumor growth. Recently, it was shown that MET amplification leads to resistance to gefitinib or erlotinib in lung cancer by driving HER3- dependent activation of the PI3K pathway.

 

References

Cooper CS, et al. (1984) Nature 311: 29-32.
Engelman JA, et al. (2007) Science 316: 1039-43.
Garcia S, et al. (2007) Int J Oncol 31: 49-58.
Hara T, et al. (1998) Lab Invest 78: 1143-53.

 

Probe Description

The ZytoDot ® 2C SPEC MET/CEN 7 Probe is a mixture of a Dinitrophenyl-labeled CEN 7 probe specific for the alpha satellite centromeric region of chromosome 7 (D7Z1) and a Digoxigenin-labeled probe specific for the MET gene at 7q31.

 

Results

In a normal interphase nucleus, using the ZytoDot ® 2C CISH Implementation Kit two red (CEN 7) and two green (MET) signals are expected. In a cell with amplification of the MET gene locus, multiple copies of the green signal or green signal clusters will be observed.

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