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ZytoDot 2C SPEC FGFR1/CEN 8 Probe

Ref : C-3050-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® 2C SPEC FGFR1/CEN 8 Probe is designed for the detection of FGFR1 gene amplification frequently observed in malignant tumors e.g. breast and prostate cancer and oral squamous cell carcinoma (OSCC).
The FGFR1 (fibroblast growth factor receptor 1) gene is located in the chromosomal region 8p12 and encodes a transmembrane receptor tyrosine kinase.
Amplification of the FGFR1 gene, observed in approximately 10% of all breast cancer samples, has revealed to be an independent prognostic factor for overall survival. FGFR1 is believed to emerge as a potential therapeutic target for lobular breast carcinomas.
In prostate cancer, FGFR1 gene amplification seems to be an important step during the transmission to hormone resistance. In OSCC, FGFR1 gene amplification, observed in nearly 20% of all cases, is indicated to contribute to oral carcinogenesis at an early stage of development.

 

References

Edwards J, et al. (2003) Clin Cancer Res 9: 5271-81.
Elbauomy Elsheikh S, et al. (2007) Breast Cancer Res 9: R23.
Freier K, et al. (2007) Oral Oncology 43: 60-6.
Lee PL, et al. (1989) Science 245: 57-60.
Lacroix-Triki M, et al. (2010) J Pathol 222: 282-98.
Swoboda A, et al. (2011) Genes Chromosomes Cancer 50: 680-8.
Turner N, et al. (2010) Cancer Res 70: 2085-94.
Wetterskog D, et al. (2012) J Pathol 226: 84-96.

 

Probe Description

The ZytoDot ® 2C SPEC FGFR1/CEN 8 Probe is a mixture of a Digoxigenin-labeled probe specific for the FGFR1 gene at 8p12 and a Dinitrophenyl-labeled CEN 8 probe specific for the alpha satellite centromeric region of chromosome 8 (D8Z2).

 

Results

In a normal interphase nucleus, using the ZytoDot ® 2C CISH Implementation Kit two green (FGFR1) and two red (CEN 8) signals are expected. In a cell with an amplification of the FGFR1 gene locus, multiple copies of the green signal or green signal clusters will be observed.

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