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ZytoDot 2C SPEC 19q13/19p13 Probe

Ref : C-3037-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® 2C SPEC 1p36/1q25 Probe and the ZytoDot ® 2C SPEC 19q13/19p13 Probe are designed for the detection of 1p and 19q deletions, respectively.
Deletions affecting the short arm of chromosome 1 (1p) are frequently found in human gliomas and euroblastomas, but also in breast, lung, endometrial, ovarian, and colorectal carcinomas. Loss of 1p is
a strong prognostic factor in patients with neuroblastoma. Since loss of 1p reliably identifies patients at high risk in stages I, II, and IVS, which are otherwise clinically favorable, more aggressive therapy may be considered in these patients. Deletions affecting the long arm of chromosome 19 (19q) are frequently found in human malignant gliomas as well as in neuroblastomas and epithelial ovarian cancers.
Several studies showed correlation of combined allelic losses at 1p36 and 19q13 with oligodendroglioma histology and association with both chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. Hence,
determination of 1p and 19q status may aid therapeutic decisions and predict outcome in patients with anaplastic oligodendrogliomas.

 

References

Barbashina V, et al. (2005) Clin Cancer Res 11: 1119-28.
Cairncross JG, et al. (1998) J Natl Cancer Inst 90: 1473-9.
Capper D, et al. (2010) Acta Neuropathol 121: 241-52.
Caron H, et al. (1996) N Engl J Med 334: 225-30.
Elsir T, et al. (2011) Br J Cancer 11: 1747-54.
Hoeller S, et al. (2012) Hum Pathol 43: 405-12.
Lass U, et al. (2012) Brain Pathol [Epub ahead of print].
Ragnarsson G, et al. (1999) Br J Cancer 79: 1468-74.
Rosenberg JE, et al. (1996) Oncogene 13: 2483-5.
Smith JS, et al. (1999) Oncogene 18: 4144-52.
Smith JS, et al. (2000) Genes Chromosomes Cancer 29: 16-25.
White PS, et al. (2005) Oncogene 24: 2684-94.
Woelfel C, et al (2011) Cancer Genet 204: 671-6.

 

Probe Description

The ZytoDot ® 2C SPEC 1p36/1q25
Probe is a mixture of a Dinitrophenyl-labeled 1p36 probe specific for the smallest region of consistent deletion (SRD) of chromosome 1 defined in neuroblastoma at 1p36.31 and a Digoxigenin-labeled 1q25 probe specific for 1q25.3.

The ZytoDot ® 2C SPEC 19q13/19p13
Probe is a mixture of a Dinitrophenyl-labeled 19q13 probe specific for the region of common deletion in gliomas at 19q13.32 and a Digoxigenin-labeled 19p13 probe specific for 19p13.3.

 

Results

In a normal interphase nucleus, using the ZytoDot ® 2C SPEC 1p36/1q25 Probe in combination with ZytoDot ® 2C CISH Implementation Kit, two red (1p) and two green (1q) signals are expected. In a cell with deletions affecting the 1p36 locus, one or no copy of the red signal will be observed.
Using the ZytoDot ® 2C SPEC 19q13/ 19p13 Probe in combination with the ZytoDot ® 2C CISH Implementation Kit, two red (19q) and two green (19p) signals are expected in a normal interphase nucleus. In a cell with deletions affecting the 19q13 locus, one or no copy of the red signal will be observed.

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