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ZytoLight SPEC NMYC/2q11 Dual Color Probe

Ref : Z-2074-200 - Nº Test : 20 - Format : 0,2 ml
Manufacturer: ZytoVision


The ZytoLight ® SPEC NMYC/2q11 Dual Color Probe is designed for the detection of NMYC amplification which represents the most powerful unfavorable prognostic factor for neuroblastoma. Less frequently amplifications are found in retinoblastoma, small cell lung cancer, astrocytoma and other tumors derived from the neuroectoderm. The NMYC (v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived) gene is located in the chromosomal region 2p24.3 and encodes a 62-64 kDa transcription factor mainly expressed in the developing nervous system. Amplification of the NMYC gene is found in about 25% of primary neuroblastomas and is strongly associated with rapid tumor progression, advanced stages of the disease, and poor prognosis. Hence, amplification status is increasingly being used for stratification of patients to different treatment protocols.



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Probe Description

The ZytoLight ® SPEC NMYC/2q11 Dual Color Probe is a mixture of a green fluorochrome direct labeled SPEC NMYC probe hybridizing to the human NMYC gene in the chromosomal region 2p24.3 and an orange fluorochrome direct labeled SPEC 2q11 probe. The SPEC 2q11 probe is specific for the LAF4 (lymphoid nuclear protein related to AF4) gene region in 2q11.2. Due to cross-hybridizations of chromosome 2 alpha satellites to other centromeric regions, probes specific for 2q11 are frequently used for chromosome 2 copy number detection.



In a normal interphase nucleus, two orange and two green signals are expected. In a cell with amplification of the NMYC gene locus, multiple copies of the green signal or green signal clusters will be observed.

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