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ZytoLight SPEC EGFR/CEN 7 Dual Color Probe

Ref : Z-2033-50 - Nº Test : 5 - Format : 0,05 ml
Manufacturer: ZytoVision
Description

Background

The ZytoLight ® SPEC EGFR/CEN 7 Dual Color Probe is designed for the detection of EGFR gene amplification frequently observed in solid neoplasms including non-small-cell lung cancer (NSCLC) and glioblastoma. The EGFR gene (a.k.a. ERBB1 and HER1) is located in the chromosomal region 7p12 and encodes a transmembrane glycoprotein acting as a cellular growth factor receptor. The protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfamily also including ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4). Overexpression of EGFR has been shown in a number of tumor entities and is associated with poor prognosis. EGFR copy number identified by FISH is thought to be a molecular predictor in neoplasms.

 

References

Balla P, et al. (2011) Histopathology 59: 376-89.
Brunner K, et al. (2010) Anal Quant Cytol Histol 32: 78-89.
Cappuzzo F, et al. (2005) J Natl Cancer Inst 97: 643-55.
Ettl T, et al. (2012) Br J Cancer 106: 719-26.
Gogas H, et al. (2010) Clin Breast Cancer 10: 230-7.
Gonçalves A, et al. (2008) BMC Cancer 8: 169ff.
Kondo I & Shimizu N (1983) Cytogenet Cell Genet 35: 9-14.
Libermann TA, et al. (1985) J Cell Sci Suppl 3: 161-72.
Merlino GT, et al. (1985) J Clin Invest 75: 1077-9.
Murray S, et al. (2012) J Exp Clin Cancer Res 31: 77.
Sassen A, et al. (2008) Breast Cancer Res 10: R2.
Sassen A, et al. (2009) Breast Cancer Res 11: R50.
Tovey SM, et al. (2004) Breast Cancer Res 6: 246-51.

 

Probe Description

The SPEC EGFR/CEN 7 Dual Color Probe is a mixture of an orange fluorochrome direct labeled CEN 7 probe specific for the alpha satellite centromeric region of chromosome 7 (D7Z1) and a green fluorochrome direct labeled SPEC EGFR probe specific for the EGFR gene at 7p12.

 

Results

In a normal interphase nucleus, two orange and two green signals are expected. In a cell with amplification of the EGFR gene locus, multiple copies of the green signal or green signal clusters will be observed.

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