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ZytoDot SPEC NMYC Probe

Ref : C-3029-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC NMYC Probe is designed for the detection of NMYC amplification which represents the most powerful unfavorable prognostic factor for neuroblastoma. Less frequently amplifications are found in retinoblastoma, small cell lung cancer, astrocytoma and other tumors derived from the neuroectoderm. The NMYC (v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived) gene is located in the chromosomal region 2p24.3 and encodes a 62-64 kDa transcription factor normally expressed in the developing nervous system and other selected tissues. The NMYC oncogene is amplified in about 25% of primary neuroblastomas and 90% of tumor-derived cell lines. Additional copies are rarely located at the normal locus but are detected as double minute chromosomes or homogeneously staining regions. Amplification of the NMYC gene is strongly associated with rapid tumor progression, advanced stages of the disease, and poor prognosis. Hence, amplification status is increasingly being used for stratification of patients to different treatment protocols.

 

References

Kaneko M, et al. (1998) Med Pediatr Oncol 31: 1-7.
Lee WH, et al. (1984) Nature 309: 458-60.
Maris JM, et al (2007) Lancet 369: 2106-20.
Slamon DJ, et al (1986) Science 232: 768-72.
Suita S, et al. (2007) J Pediatr Surg 42: 489-93.
Thorner PS, et al. (2006) Am J Surg Pathol 30: 635-42.

 

Probe Description

The ZytoDot ® SPEC NMYC Probe is a Digoxigenin- labeled clone contig specific for the NMYC gene at 2p24.3, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

 

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the NMYC gene locus or aneuploidy of chromosome 2 will show multiple dots or large signal clusters.

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