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ZytoDot SPEC FGFR1 Probe

Ref : C-3023-400 - Nº Test : 40 - Format : 0,4 ml
Manufacturer: ZytoVision
Description

Background

The ZytoDot ® SPEC FGFR1 Probe is designed for the detection of FGFR1 gene amplification frequently observed in malignant tumors e.g. breast and prostate cancer and oral squamous cell carcinoma (OSCC). The FGFR1 (fibroblast growth factor receptor 1) gene is located in the chromosomal region 8p12 and encodes a transmembrane receptor tyrosine kinase. Amplification of the FGFR1 gene, observed in approximately 10% of all breast cancer samples, has revealed to be an independent prognostic factor for overall survival. FGFR1 is believed to emerge as a potential therapeutic target for lobular breast carcinomas. In prostate cancer, FGFR1 gene amplification seems to be an important step during the transmission to hormone resistance. In OSCC, FGFR1 gene amplification, observed in nearly 20% of all cases, is indicated to contribute to oral carcinogenesis at an early stage of development.

 

References

Edwards J, et al. (2003) Clin Cancer Res 9: 5271-81.
Elbauomy Elsheikh S, et al. (2007) Breast Cancer Res 9: R23.
Freier K, et al. (2007) Oral Oncology 43: 60-6.
Lacroix-Triki M, et al. (2010) J Pathol 222: 282-98.
Lee PL, et al. (1989) Science 245: 57-60.
Reis-Filho JS, et al. (2006) Clin Cancer Res 12: 6652-62.
Turner N, et al. (2010) Cancer Res 70: 2085-94.
Wetterskog D, et al. (2012) J Pathol 226: 84-96.

 

Probe Description

The ZytoDot ® SPEC FGFR1 Probe is a Digoxigenin- labeled clone contig specific for the FGFR1 gene at 8p12, processed by the unique ZytoVision ® Repeat Subtraction Technique resulting in advanced specificity and less background.

 

Results

In normal cells, two distinct dot-shaped signals per nucleus will be observed. Nuclei with amplification of the FGFR1 gene locus or polysomy of chromosome 8 will show multiple dots or large signal clusters.

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