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Lambda Light Chain-FITC

Ref: AP10367C - Format: Concentrated - 1 mL - Host: Rabbit
DS  Imagen 1
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30, the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain are present in serum (kappa, 1.6-15.2 mg/L; lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins).

Polyclonal
Isotype: Rabbit IgG
Immunogen: Pool of human lambda light chain isolated from the urine of patients with Bence Jones Proteinuria.
Staining pattern: Cytoplasmatic and secreted.
Positive control: Tissue sample from tonsil.

APPLICATIONS:
This antibody is designed for the specific localization of human Kappa Light Chain using IF techniques in formalin-fixed, paraffin-embedded tissue sections and frozen tissue.

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