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p504S [13H4]

Ref: AP10374C - Clone: 13H4 - Host: Rabbit - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Alpha methylacyl-CoA-racemase (AMACR), also known as p504s is an enzyme involved in the metabolism of branched-chain fatty acids. p504s is expressed in various normal tissues and carcinomas, while it is overexpressed over 30- fold in prostate carcinoma compared to benign glandular tissues1. When p504s is overexpressed in atypical glands without basal cells, it establishes a diagnosis of prostatic carcinoma. High-grade prostatic intraepithelial neoplasia, atypical adenomatous hyperplasia and urothelial carcinoma may also express p504s.

Clone: 13H4
Isotype: IgG
Immunogen: Human AMACR polypeptide.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from prostate carcinoma.

This antibody is designed for the specific localization of human p504S using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
AMACR (p504S) serves as a marker of prostatic adenocarcinomas (although in 18% of carcinomas of the prostate may be negative) and its potential help to establish the differential diagnosis with benign prostate and other conditions that can be confused with neoplasia as high-grade prostatic intraepithelial (PIN), atypical adenomatous hyperplasia, nephrogenic adenoma, especially in the immunohistochemical panel included cytokeratins of high molecular weight (34bE12), cytokeratin 5/6 or p63 protein that stained the basal cell layer absent in neoplastic glands. Although some hepatocellular carcinomas and papillary renal tumors express detectable amounts of p504S by IHC, breast adenocarcinoma, adrenal, bile ducts, thyroid, endometrium and ovary are negative or positive in rare cases. The other malignancies (melanoma, thymoma, squamous carcinomas, basaliomas, germ cell tumors, carcinomas neuroendorinos, soft tissue tumors) are consistently negative.

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