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p27Kip1 [DCS-72]

Ref: AP10291C - Clone: DCS-72 - Host: Mouse - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
Cell cycle progression is regulated by a series of cyclin-dependent kinases consisting of catalytic subunits, designated Cdks, as well as activating subunits, designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has recently been described that function as “mitotic inhibitors.” These include p21, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16; and a more recently described p16-related inhibitor designated p15. A p21-related protein, p27, has been described as a negative regulator of G1 progression and speculated to function as a possible mediator of G1 arrest. p27 interacts strongly with D-type cyclins and Cdk4 in vitro and, to a lesser extent, with cyclin E and Cdk2.

Clone: DCS-72
Isotype: IgG1
Immunogen: BALB/C mice were injected with mouse recombinant p27Kip 1 protein.
Staining pattern: Nuclear.
Positive control: Tissue sample from prostate carcinoma.

APPLICATIONS:
This antibody is designed for the specific localization of human p27Kip1 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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