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P-Glycoprotein (MDR-1) [JSB-1]

Ref: AP10219 - Clone: JSB-1 - Host: Mouse - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
Cells which are selected for the resistance of a cytotoxic drug can be resistant to a wide drugs variety with different structures and target cells. This phenomenon is called Multiple Drugs Resistance (MDR). MDR proteins belong to a highly conserved transporter superfamily which binds ATP. MDR proteins are ATP-depending bombs which transport a variety of structural different agents, from ions to peptides. They are involved in the multiple drugs resistance development observed in human cancer cells after a long chemotherapy. The classic form of multidrug is the increase of the MDR protein level, but not in all multidrug cases.
MDR-1, also called P-glycoprotein, is a transmembrane protein, which stains the blood-brain barrier and works like a bomb transporting a variety of agents. In human population there are 15 polymorphisms on the MDR-1 gen.

Clone: JSB1
Isotype: IgG1
Immunogen: Multidrug-resistant Chinese hamster ovary cell line (CHrC5).
Staining pattern: Cell membrane.
Positive control: Tissue sample from liver or colon.

APPLICATIONS:
This antibody is designed for the specific localization of human P-Glycoprotein using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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