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P-Cadherin [56C1]

Ref: AP10373C - Clone: 56C1 - Host: Mouse - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
Cadherins are calcium dependent cell adhesion molecules, which play important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. They are expressed in tissue specific manner and and are required for assembly of cells into solid tissue. Individual cadherin molecules are known to co-operate with each other to form a linear cell adhesion zipper. In adhesion junctions cadherins are bound to β and γ catenins which in turn bind to α catenin, an actin binding protein. Cadherins play important part in tumor invasion and metastasis. P-cadherin is selectively expressed in basal and parabasal layers of stratified epithelia. It may be involved in the final stages of tumor progression in epidermal carcinoma. Changes in P-cadherin expression have been implicated in breast and melanocytic tumors.

Clone: 56C1
Isotype: IgG
Immunogen: Recombinant protein corresponding to extracellular domain of human P-Cadherin.
Staining pattern: Cell membrane.
Positive control: Tissue sample from skin, placenta or tonsil.

APPLICATIONS:
This antibody is designed for the specific localization of human P-Cadherin using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
Immunohistochemical identification of P-cadherin in normal or neoplastic cells.

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