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MiTF (Microphthalmia Transcription Factor) [Polyclonal]

Ref: AP10271 - Clone: Polyclonal - Host: Rabbit - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description p>SUMMARY, EXPLANATION AND LIMITATIONS:
MiTF (Microphthalmia associated Transcription Factor) is a helix-loop-helix transcription factor implicated in pigmentation and mast and bone development. MiTF gene mutation produces Waardenburg IIA and the Tietze syndrome, they causes pigmentation and deafness disorders, by melanocytes deficiencies in inner ear. There are two known isoforms of the MiTF gene which differ in 66 amino acids in N-terminus. The shorter MiTF isoform (it runs two bands, 52 and 56 kDa) specific of melanocytes is MiTF, which expresses either in normal or malignant melanocytes. The other forms MiTF-A, MiTF-C and MiTF-H runs a bands cluster between 60-70 kDa, they differ structurally of MiTF in the N-terminus, they are expressed in osteoclasts and mast cells and heart; and the B16 melanoma line cell (but not in other line cells). MiTF plays an important role in several cell type differentiation.

Polyclonal
Isotype: IgG
Immunogen: Synthetic peptide corresponding to human MitF.
Staining pattern: Nuclear.
Positive control: Tissue sample from melanoma.

APPLICATIONS:
This antibody is designed for the specific localization of human MiTF using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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