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EGFR (Epidermal Growth Factor Receptor) [111.6]

Ref: AP10195 - Clone: 111.6 - Host: Mouse - Method: P - Format: Ready to use
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
EGFR is type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2,-3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Clone: 111.6
Isotype: IgG1
Immunogen: Extracellular domain of human recombinant EGFR protein.
Staining pattern: Cell membrane.
Positive control: Tissue sample from placenta or squamous cell carcinoma.

APPLICATIONS:
This antibody is designed for the specific localization of human EGFR using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.

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