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C4d [10-11]

Ref: AP10360C - Clone: 10-11 - Host: Mouse - Method: P,F - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova
Description

SUMMARY, EXPLANATION AND LIMITATIONS:
This antibody recognises the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. C4d’s short half-life means that C4d is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.

Clone: 10-11
Isotype: IgG1
Immunogen: Native, from human plasma.
Staining pattern: Cytoplasmic/Secreted.
Positive control: Tissue sample from kidney.

APPLICATIONS:
This antibody is designed for the specific localization of human C4d using IHC techniques in frozen tissue.

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