Follow Us

Bcl-2 [124]

Ref: AP10469C - Clone: 124 - Host: Mouse - Method: P - Format: Concentrated
DS  Imagen 1   MSDS  Imagen 2
Manufacturer: Gennova

Apoptosis, or programmed cell death may be initiated in two ways: 1) the extrinsic pathway by activation of cell surface receptors belonging to the family of tumor necrosis factor and 2) dependent pathway of intracellular stress, irradiation, or activation cytokine receptor. In the latter pathway, the proteins of the Bcl-2 are key regulators of the intracytoplasmic caspase activation triggering apoptosis, so that the members antagonists thereof containing three or four specific regions of homology, whereas for in contrast, proapoptotic members of the group (Bax, Bak, Bcl-xS, Bad, Bik) only shared between them and the rest of the family a short 9-16 amino acid domain called BH3.

Clone: 124
Isotype: IgG1/kappa
Immunogen: Human Bcl-2 protein.
Staining pattern: Cytoplasmic.
Positive control: Tissue sample from tonsil, follicular lymphoma.

This antibody is designed for the specific localization of human Bcl-2 using IHC techniques in formalin-fixed, paraffin-embedded tissue sections.
In normal lymphoid tissue, the anti-Bcl-2 reacts with B lymphocytes small follicular mantle zone and numerous small lymphoid cells within the areas T. The cells are stained in the germinal center corresponding to T helper cells that physiologically colonize it. In the thymus cells are colored some of the core while in the cortex immunostaining is weak or nonexistent. In hematopoietic tissues often stained some cells represent primarily reactive infiltration of leukocytes. In neoplasms should be distinguished between in vitro diagnostic utility of this antibody and its use as a marker to define the prognosis of the tumor. In the first case, the germinal centers neoplastic most follicular non-Hodgkin lymphomas express high levels of Bcl-2 protein, while normal or hyperplastic germinal centers are negative.

Reviw on bokmaker Number 1 in uk William Hill
Full Reviw on best bokmaker - Ladbrokes full information
Play Casino Bet365 read more.


NOTE! This site uses cookies and similar technologies.

If you not change browser settings, you agree to it.

I understand
Ranking bookmakers sites